Protective effect of Crocus sativus L. (Saffron) extract on spinal cord ischemia-reperfusion injury in rats
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Abstract:
Objective(s): Ischemia/reperfusion (I/R) injury of spinal cord is leading to the paraplegia observed. In this study, we investigated the protective effect of the saffron extract on spinal cord I/R injury. Materials and Methods: Thirty five male Sprague-Dawley rats were divided into 5 groups: intact, sham surgery, normal saline (NS), low dose saffron aqua extract, high dose saffron aqua extract. Results: The mean motor deficit index (MDI) scores were significantly lower in the saffron extract groups than in the NS group at 48 hr after spinal cord ischemia (P
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protective effect of crocus sativus l. (saffron) extract on spinal cord ischemia-reperfusion injury in rats
objective(s): ischemia/reperfusion (i/r) injury of spinal cord is leading to the paraplegia observed. in this study, we investigated the protective effect of the saffron extract on spinal cord i/r injury. materials and methods: thirty five male sprague-dawley rats were divided into 5 groups: intact, sham surgery, normal saline (ns), low dose saffron aqua extract, high dose saffron aqua extract....
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Saffron and its constituents have been shown to decrease ischemia-reperfusion (I/R) injury in kidney or brain tissues. In this study, the effects of saffron ethanolic extract and its constituents, crocin and safranal, were evaluated in skeletal muscle during I/R injury. Hind limb ischemia was induced using clamping the common femoral artery and vein. After 2 h ischemia, the clamp of the femoral...
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Journal title
volume 20 issue 3
pages 334- 337
publication date 2017-03-01
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